Interpersonal Consequences of Deceptive Expressions of Sadness.

Emotional expressions evoke predictable responses from observers; displays of sadness are commonly met with sympathy and help from others. Accordingly, people may be motivated to feign emotions to elicit a desired response. In the absence of suspicion, we predicted that emotional and behavioral responses to genuine (vs. deceptive) expressers would be guided by empirically valid cues of sadness authenticity. Consistent with this hypothesis, untrained observers (total N = 1,300) reported less sympathy and offered less help to deceptive (vs. genuine) expressers of sadness. This effect was replicated using both posed, low-stakes, laboratory-created stimuli, and spontaneous, real, high-stakes emotional appeals to the public. Furthermore, lens models suggest that sympathy reactions were guided by difficult-to-fake facial actions associated with sadness. Results suggest that naive observers use empirically valid cues to deception to coordinate social interactions, providing novel evidence that people are sensitive to subtle cues to deception.

Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics.

PURPOSE: Thyroid cancer is frequently difficult to diagnose due to an overlap of cytologic features between malignant and benign nodules. This overlap leads to unnecessary removal of the thyroid in patients without cancer. While providing some improvement over cytopathologic diagnostics, molecular methods frequently fail to provide a correct diagnosis for thyroid nodules. These approaches are based on the difference between cancer and adjacent thyroid tissue and assume that adjacent tissues are the same as benign nodules. However, in contrast to adjacent tissues, benign thyroid nodules can contain genetic alterations that can be found in cancer.Experimental Design: For the development of a new molecular diagnostic test for thyroid cancer, we evaluated DNA methylation in 109 thyroid tissues by using genome-wide single-base resolution DNA methylation analysis. The test was validated in a retrospective cohort containing 65 thyroid nodules. RESULTS: By conducting reduced representation bisulfite sequencing in 109 thyroid specimens, we found significant differences between adjacent tissue, benign nodules, and cancer. These tissue-specific signatures are strongly linked to active enhancers and cancer-associated genes. Based on these signatures, we developed a new epigenetic approach for thyroid diagnostics. According to the validation cohort, our test has an estimated specificity of 97% [95% confidence interval (CI), 81-100], sensitivity of 100% (95% CI, 87-100), positive predictive value of 97% (95% CI, 83-100), and negative predictive value of 100% (95% CI, 86-100). CONCLUSIONS: These data show that epigenetic testing can provide outstanding diagnostic accuracy for thyroid nodules.See related commentary by Mitmaker et al., p. 457.

When lying changes memory for the truth.

In the legal field, victims and offenders frequently lie to avoid talking about serious incidents, such as past experiences of sexual abuse or criminal involvement. Although these individuals may initially lie about an experienced event, oftentimes these same people eventually abandon their lies and are forthcoming with what truly happened. To date, it is unclear whether such lying affects later statements about one's memory for the experienced event. The impetus of the present review is to compile the current state of knowledge on the effects of lying on memory. Based on existing literature, we will describe how deceptive strategies (e.g., false denials) regarding what is remembered may affect memory in consequential ways, such as forgetting of details, falsely remembering features that were not present, or a combination of both. It will be argued that the current literature suggests that mnemonic outcome is contingent on the type of lie and we will propose a theoretical framework outlining which forms of lying likely result in certain memory outcomes. Potential avenues of future research also will be discussed.

CSI (Crime Scene Induction): Creating False Memories of Committing Crime.

We describe two merging lines of empirical inquiry: entire false memories for autobiographical events and false confessions. A recent study showed that people can be led to remember, and confess to, perpetrating serious crimes that never occurred when confronted with suggestive interview tactics commonly used in police interrogations.

Prime time news: the influence of primed positive and negative emotion on susceptibility to false memories.

We examined the relation between emotion and susceptibility to misinformation using a novel paradigm, the ambiguous stimuli affective priming (ASAP) paradigm. Participants (N = 88) viewed ambiguous neutral images primed either at encoding or retrieval to be interpreted as either highly positive or negative (or neutral/not primed). After viewing the images, they either were asked misleading or non-leading questions. Following a delay, memory accuracy for the original images was assessed. Results indicated that any emotional priming at encoding led to a higher susceptibility to misinformation relative to priming at recall. In particular, inducing a negative interpretation of the image at encoding led to an increased susceptibility of false memories for major misinformation (an entire object not actually present in the scene). In contrast, this pattern was reversed when priming was used at recall; a negative reinterpretation of the image decreased memory distortion relative to unprimed images. These findings suggest that, with precise experimental control, the experience of emotion at event encoding, in particular, is implicated in false memory susceptibility.